Unravelling the mechanisms of genomic processes at the single-molecule level
Our goal is to obtain a deeper understanding of the molecular mechanisms that underpin essential genomic processes. A key focus of our research is on understanding how changes in DNA structure can regulate genome function, and how DNA-protein interactions can drive changes in genome architecture. To achieve this, we use a multi-disciplinary approach that combines novel single-molecule strategies (based on techniques such as optical tweezers and fluorescence imaging) with biochemistry.
We are based at the Department of Structural and Molecular Biology at University College London and are a member of the Institute of Structural and Molecular Biology, a joint institute between University College London and Birkbeck, University of London.